Dengue virus (DENV) is a mosquito-borne virus with four distinct serotypes. Primary infection by any of the four serotypes may result in dengue fever or, in severe cases, progress to dengue hemorrhagic fever/dengue shock syndrome. Recent studies have challenged dogma in the dengue field by finding that serotype-cross-reactive neutralizing antibody titers in serum of children in a cohort study in Nicaragua increased marginally in the time between primary and secondary DENV infection rather than decreasing over time, implying re-exposure to DENV. Maritza will use a novel method the Quad-color Fluorospotto investigate whether homotypic and heterotypic boosting observed previously in serum is also seen in memory B cells obtained from dengue cohort participants from Nicaragua. Her work will have important implications for both natural immunity and dengue vaccine efficacy over time.
Most evaluations of Beat Generation authors tend to overlook the significance of race and sexuality in the formation of the quintessential identity of the 1960s culture of dissent. Adonis thesis will explore the Beat oeuvres of Bob Kaufman and Amiri Baraka primarily through queer theory and Fanonian Critical Race Theory. He will examine the nexus of marginalized experiences between these poets, which centers on homophobia and racism, and produces cultural isolation, alienation/imprisonment, and a devastating psychic loneliness. He will also consider the subject of their poetry, who is extremely alien to the 1960s quintessential American, to understand how despite this subjects loneliness, nonconformity, and bohemian ethos, its unprecedented relatability polarizes a shift in American Culture, thus redefining what it meant to be an American.
In 1542, a short religious text from about the year 1400 was made into a single surviving edition by a relatively unknown publisher, Richard Lant. Though his particular attempt at revitalization was modest, the religious turmoil of his period caused others like him to reproduce an array of religious texts from the Middle Ages, revising their language into new editions for Early Modern English. What do these changes in language mean for a new religious context and system of interpretation? Working to catch hold of some of the threads of new Christian thought during these two periods, Rieson will be traveling to the British Library in London and other archives in the U.K. in order to gain access to the Middle English manuscripts from which their Early Modern editions were made.
Strain engineering is a ubiquitous technique utilized in the semiconductor industry to modulate and engineer the properties of semiconducting electronic materials. Various processes such as advanced high performance transistors, solid-state lasers, and integrated circuits adopt strain engineering to further optimize their performance. Simultaneously, two dimensional transition metal dichacogenides (TMDCs) have demonstrated their great potentials as the next optoelectronics and extremely scaled electronics; they can be scaled down to the atomic limit to be used for electronics. However, to date the merits of strain engineering have not been sufficiently employed nor explored in the field of TMDC-based scaled optoelectronics. Geun Ho aims to expand the strain engineering of TMDCs, and perform systematic experimental studies of strained TMDCs in order to optimize their optoelectronic performances.
All too often, patients in psychiatric hospitals are involved in violent incidents with other patients and hospital staff. These incidents incur significant economic, social and human costs. Although most research has focused on identifying patient characteristics that contribute to violence (e.g., young age, past violence), there is growing recognition that rates of violence can vary tremendously based on the environment. Sara will be using an instrument, PRISM (Promoting Risk Intervention by Situational Management), to examine how environmental factors contribute to variation in rates of institutional violence across units at Napa State Hospital. Through observations of physical surroundings, interviews with patients and staff, and discussion with management personnel, her findings aim to illuminate factors that can be targeted by administrators in violence reduction and prevention efforts.
It is not yet known what causes autism spectrum disorder (ASD) on a molecular level, but recently, 65 ASD risk genes have been identified by a lab at UCSF. Albert is focusing on one of these genes, called Neurexin 1. He will be using CRISPR/Cas9 genome editing to knock out Nrxn1 in Xenopus tropicalis frogs and observing the phenotypic effects, such as increases and reductions in cell proliferation and differentiation as well as changes in regulation of other neural genes. Alberts goal is to illuminate the roles of this gene in healthy neurodevelopment to gain insight into how a mutation can lead to ASD. This research project will develop the groundwork for investigating other autism genes, taking us closer to defining the molecular biological etiology of ASD.
As the historic prison boom of the past thirty years comes to a halt in California, a nascent jailr boom has snuck onto the scene. Forty out of fifty-eight counties in California are in various stages of building or renovating jails, the most pronounced characteristic among these new jail projects being their emphasis on mental health treatment. Susan will conduct secondary and archival research, interviews with various stakeholders, and observation of political events concerning jail expansion and mental health to investigate the political, economic, and social forces facilitating the newest expression of carceral expansion in California the mental health jail. Her investigation comes during a unique window of opportunity to shift mental health and criminal justice policy due to declining incarceration and increased public enthusiasm for community-based alternatives to incarceration.
Throughout the 1900s Berkeley Anthropologists documented the ethnographic information of many Native Californian tribes for fear that their lifeways and languages were soon to become extinct in the wake of the burgeoning United States. The Bancroft Library is now steward of these ethnographic collections. While the public institution is responsible to make the collections available to all without bias, one Native Californian community has protested that open access to these collections leaves their community vulnerable to multiple dangers such as misrepresentation in academic articles and potential looting of the sacred sites described therein. Marks research seeks to discover how public access to these ethnographic collections impacts the descendant communities and asks who has the right to access the ethnographic information of these Native Californian tribes?
Rural areas compose 86% of Mexicos territory and account for 36% of the population while rural GDP per capita ranges between 27% and 43% of the national average. To address this urban/rural developmental divide, the Secretariat of Tourism created the Programa Pueblos Mgicos (PPM). Its goal was to raise local levels of wellbeing by promoting economic development through tourism. By carrying out a sense of community survey, collecting socioeconomic data, and interviewing residents and town officials, Adrin will explore whether the PPM has resulted in the abatement or aggravation of unequal distributions of wealth in Talpa de Allende, Jalisco. Adrins project will analyze subsets of Talpas population to explore whether the economic development arising from this program has improved the living standards of those who need it the most.
In 1873, more than 100 Buffalo Soldiers at Fort Stockton, Texas signed a petition requesting formal censure of the post surgeon for his racist refusal to treat a sick and dying man. The officers responded by putting the soldiers on trial for mutiny. Nicks research will look at how these soldiers, most of whom were born into enslavement, came to understand and express their rights as United States citizens. This research will combine primary documentary sources, housed at the National Archives and Fort Stockton, with secondary literature on African American agency, literacy, and solidarity in the Reconstruction Era. Through this work, Nick will explore how the law was used to both assert and contest notions of personhood a theme which remains as relevant today as it was in 1873.