Role of Sgk in Apoptotic Signaling
Brian will investigate apoptosis, an active choice made by an individual cell to embark on a pathway that ultimately results in its demise. It is generally accepted that apoptosis plays an important role in eliminating damaged cells and maintaining a stable cellular environment; however, relatively little is known about the regulator and effector molecules that may be involved in initiating and relaying apoptotic signals. By increasing our understanding of the regulatory role of the serum and glucocorticoid regulated kinase (sgk) protein in apoptotic signaling, Brian’s project will have implications for the medical treatment of diseased cells, including the development of new drugs for treating cancer, viruses and strokes.
- Mentor: Professor Gary Firestone, Molecular & Cell Biology