Mechanisms of Acute Myocardial Dysfunction Induced by a Bacterial Superantigen, SEB and a Viral Superantigen, SARS-CoV-2 Spike Protein
Seung Won will be studying the mechanism of acute myocardial dysfunction caused by a bacterial superantigen: staphylococcal enterotoxin B (SEB) using a rabbit model in an experimental ICU setting. While SEB is known to cause toxic shock syndrome, whether it causes a systemic inflammatory response or causes direct heart damage is unknown. Furthermore, SEB has been found to have a similar structure to the SARS-CoV-2 spike protein, suggesting similar superantigenic activity. Findings will hopefully provide new insights into therapeutics for SEB and SARS-CoV-2 induced myocardial dysfunction.
- Major: Molecular & Cell Biology, Korean minor
- Mentor: Binh Diep, UCSF Medicine - HIV, Infectious Disease & Global Medicine